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Cancer metastasis is the spread and growth of tumor cells from the original neoplasm to further organs. This review analyzes the role of nitric oxide (NO^{radical dot}), a signaling molecule, in the regulation of cancer formation, progression, and metastasis. The action of NO^{radical dot} on cancer relies on multiple factors including cell type, metastasis stage, and organs involved. Various chemotherapy drugs cause cells to release NO^{radical dot}, which in turn induces cytotoxic death of breast, liver, and skin tumors. However, NO^{radical dot} has also been clinically connected to a poor cancer prognosis because of its role in angiogenesis and intravasation. This supports the claim that NO^{radical dot} can be characterized as both pro-metastatic and anti-metastatic, depending on specific factors. The inhibition of cell proliferation and anti-apoptosis pathways by NO^{radical dot} donors has been proposed as a novel therapy to …