作者
Colin S Ong, Anne M Keogh, Steven Kossard, Peter S Macdonald, Phillip M Spratt
发表日期
1999/1/1
期刊
Journal of the American Academy of Dermatology
卷号
40
期号
1
页码范围
27-34
出版商
Mosby
简介
Background
Cutaneous malignancy is a major cause of morbidity in organ transplant recipients.
Objective
Our purpose was to report on skin cancer in Australian heart transplant recipients with analysis of HLA factors.
Methods
We reviewed histologically proven skin cancers in the first 455 patients undergoing organ transplantation in Sydney, Australia.
Results
The cumulative incidence of skin cancer was 31% at 5 years and 43% at 10 years with a squamous cell carcinoma/basal cell carcinoma ratio of 3:1. Caucasian origin, increasing age at transplantation, and duration of follow-up were significantly associated with skin cancer. Skin cancer accounted for 27% of 41 deaths occurring after the fourth year. Recipient HLA-DR homozygosity was associated with skin cancer overall, whereas HLA-DR7 was a protective factor in skin cancer overall, squamous cell carcinoma, and Bowen’s disease. HLA-A1 and HLA-A11 …
引用总数
学术搜索中的文章
CS Ong, AM Keogh, S Kossard, PS Macdonald… - Journal of the American Academy of Dermatology, 1999