作者
Robert G Weintraub, Christopher Semsarian, Peter Macdonald
发表日期
2017/7/22
来源
The Lancet
卷号
390
期号
10092
页码范围
400-414
出版商
Elsevier
简介
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. The most common presenting symptoms relate to congestive heart failure, but can also include circulatory collapse, arrhythmias, and thromboembolic events. Secondary neurohormonal changes contribute to reverse remodelling and ongoing myocyte damage. The prognosis is worst for individuals with the lowest ejection fractions or severe diastolic dysfunction. Treatment of chronic heart failure comprises medications that improve survival and reduce hospital admission—namely, angiotensin converting enzyme inhibitors and β blockers …
引用总数
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学术搜索中的文章
RG Weintraub, C Semsarian, P Macdonald - The Lancet, 2017