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Hyperlipidemia is one of the common risk factors of cardiovascular disease. The effects of Ajwa date seed powder on serum lipid profile in human beings in this randomized, double-blind, placebo-controlled clinical study were evaluated. Hypercholesterolemic patients were instructed to take the Ajwa date seed powder (200 mg of seed powder filled in each capsule) three times daily after a meal for 90 days as a form of treatment once distributing them to intervention (n = 30) or placebo (n = 28) group. Each group was similar in essential baseline characteristics with no significant differences. The primary outcome measure was total cholesterol (TC) levels. Secondary outcome measures were low-density lipoprotein (LDL), triglycerides (TG) and high-density lipoprotein (HDL). The Ajwa date seed powder yielded a 19.4 %, 22.5 %, and 25.78 % decrease in total cholesterol (TC), low-density lipoprotein (LDL), and …