作者
Roxana S Redis, Luz E Vela, Weiqin Lu, Juliana Ferreira de Oliveira, Cristina Ivan, Cristian Rodriguez-Aguayo, Douglas Adamoski, Barbara Pasculli, Ayumu Taguchi, Yunyun Chen, Agustin F Fernandez, Luis Valledor, Katrien Van Roosbroeck, Samuel Chang, Maitri Shah, Garrett Kinnebrew, Leng Han, Yaser Atlasi, Lawrence H Cheung, Gilbert Y Huang, Paloma Monroig, Marc S Ramirez, Tina Catela Ivkovic, Long Van, Hui Ling, Roberta Gafà, Sanja Kapitanovic, Giovanni Lanza, James A Bankson, Peng Huang, Stephen Y Lai, Robert C Bast, Michael G Rosenblum, Milan Radovich, Mircea Ivan, Geoffrey Bartholomeusz, Han Liang, Mario F Fraga, William R Widger, Samir Hanash, Ioana Berindan-Neagoe, Gabriel Lopez-Berestein, Andre LB Ambrosio, Sandra M Gomes Dias, George A Calin
发表日期
2016/2/18
期刊
Molecular cell
卷号
61
期号
4
页码范围
520-534
出版商
Elsevier
简介
Altered energy metabolism is a cancer hallmark as malignant cells tailor their metabolic pathways to meet their energy requirements. Glucose and glutamine are the major nutrients that fuel cellular metabolism, and the pathways utilizing these nutrients are often altered in cancer. Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk-associated rs6983267 SNP, regulates cancer metabolism in vitro and in vivo in an allele-specific manner by binding the Cleavage Factor I (CFIm) complex with distinct affinities for the two subunits (CFIm25 and CFIm68). The CCAT2 interaction with the CFIm complex fine-tunes the alternative splicing of Glutaminase (GLS) by selecting the poly(A) site in intron 14 of the precursor mRNA. These findings uncover a complex, allele-specific regulatory mechanism of cancer metabolism orchestrated by the two alleles of a long ncRNA.
学术搜索中的文章
RS Redis, LE Vela, W Lu, JF de Oliveira, C Ivan… - Molecular cell, 2016
