作者
Rocío G Urdinguio, Gustavo F Bayon, Marija Dmitrijeva, Estela G Torano, Cristina Bravo, Mario F Fraga, Lluís Bassas, Sara Larriba, Agustín F Fernández
发表日期
2015/5/1
期刊
Human reproduction
卷号
30
期号
5
页码范围
1014-1028
出版商
Oxford University Press
简介
STUDY QUESTION
Are there DNA methylation alterations in sperm that could explain the reduced biological fertility of male partners from couples with unexplained infertility?
SUMMARY ANSWER
DNA methylation patterns, not only at specific loci but also at Alu Yb8 repetitive sequences, are altered in infertile individuals compared with fertile controls.
WHAT IS KNOWN ALREADY
Aberrant DNA methylation of sperm has been associated with human male infertility in patients demonstrating either deficiencies in the process of spermatogenesis or low semen quality.
STUDY DESIGN, SIZE, DURATION
Case and control prospective study. This study compares 46 sperm samples obtained from 17 normospermic fertile men and 29 normospermic infertile patients.
PARTICIPANTS/MATERIALS, SETTING, METHODS …
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