作者
Naiara G Bediaga, Amelia Acha-Sagredo, Isabel Guerra, Amparo Viguri, Carmen Albaina, Irune Ruiz Diaz, Ricardo Rezola, María Jesus Alberdi, Joaquín Dopazo, David Montaner, Mertxe de Renobales, Agustín F Fernández, John K Field, Mario F Fraga, Triantafillos Liloglou, Marian M de Pancorbo
发表日期
2010/10
期刊
Breast cancer research
卷号
12
页码范围
1-12
出版商
BioMed Central
简介
Introduction
Identification of gene expression-based breast cancer subtypes is considered a critical means of prognostication. Genetic mutations along with epigenetic alterations contribute to gene-expression changes occurring in breast cancer. So far, these epigenetic contributions to sporadic breast cancer subtypes have not been well characterized, and only a limited understanding exists of the epigenetic mechanisms affected in those particular breast cancer subtypes. The present study was undertaken to dissect the breast cancer methylome and to deliver specific epigenotypes associated with particular breast cancer subtypes.
Methods
By using a microarray approach, we analyzed DNA methylation in regulatory regions of 806 cancer-related genes in 28 breast cancer paired samples. We subsequently performed substantial technical and biologic …
学术搜索中的文章
NG Bediaga, A Acha-Sagredo, I Guerra, A Viguri… - Breast cancer research, 2010
