作者
Diana Maržić, Miran Čoklo, Blažen Marijić, Ita Hadžisejdić, Andrea Dekanić, Mira Krstulja, Tatjana Šepić, Manuela Avirović, Tamara Braut
发表日期
2020/6/1
期刊
Pathology-Research and Practice
卷号
216
期号
6
页码范围
152974
出版商
Urban & Fischer
简介
Objective
The aim of the study was to investigate the expression of ribonuclear protein IMP3 in laryngeal carcinogenesis, together with other biomarkers of carcinogenesis (Ki-67, p53 and cyclin D1), and to evaluate their predictive values.
Methods
The study included 153 patients divided into three groups: 68 operated for primary invasive laryngeal squamous cell carcinoma (LSCC); 41 with precancerous lesions of atypical and abnormal hyperplasia; 44 with hyperplastic laryngeal nodule without atypia. Tissue microarray technique was used for immunohistochemical analysis.
Results
All markers showed statistically significant differences between the three groups. The percentage of IMP3 positive cells is statistically significantly higher in LSCC group in comparison to precancerosis and control group. The percentage of Ki-67 positive cells is statistically significantly higher in LSCC group in comparison to precancerosis …
学术搜索中的文章
D Maržić, M Čoklo, B Marijić, I Hadžisejdić, A Dekanić… - Pathology-Research and Practice, 2020