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Methods

Serum samples received from pregnant women attending the antenatal clinic of All India Institute of Medical Sciences, Rishikesh, between January 2016 to December 2019 were tested for TG-, RV-, CMV, and HSV-specific IgM and IgG by capture enzyme-linked immunoassay (ELISA). The data were then analyzed to determine the seroprevalence of the major ToRCH infections (toxoplasmosis, other (syphilis, varicella-zoster, parvovirus B19), rubella, cytomegalovirus, and herpes), and Fisher’s exact test was applied to check association with potential risk factors.

Results

Out of 165 pregnant women who were screened for the four major ToRCH pathogens, overall seroprevalence was 41.2% for TG (IgM= 13.3%; IgG= 38.2%), 80.0% for RV (IgM= 3.0%; IgG= 80.0%), 61.8% for CMV (IgM= 1.8%; IgG= 61.8%), and 42.4% for HSV (IgM= 4.3%; IgG= 40.6). TG was significantly associated with increasing maternal …