作者
Natasha Christie-Holmes, Rachel Tyli, Patrick Budylowski, Furkan Guvenc, Amit Weiner, Betty Poon, Mary Speck, Stephenie Naugler, Allen Rainville, Ayoob Ghalami, Shannon McCaw, Steven Hayes, Samira Mubareka, Scott D Gray-Owen, Ori D Rotstein, Rita A Kandel, James A Scott
发表日期
2021/10/1
期刊
American Journal of Infection Control
卷号
49
期号
10
页码范围
1227-1231
出版商
Mosby
简介
Background
The COVID-19 pandemic highlighted the need for evidence-based approaches to decontamination and reuse of N95 filtering facepiece respirators (FFRs). We sought to determine whether vapourized hydrogen peroxide (VHP) reduced SARS-CoV-2 bioburden on FFRs without compromising filtration efficiency. We also investigated coronavirus HCoV-229E as a surrogate for decontamination validation testing.
Methods
N95 FFRs were laced with SARS-CoV-2 or HCoV-229E and treated with VHP in a hospital reprocessing facility. After sterilization, viral burden was determined using viral outgrowth in a titration assay, and filtration efficiency of FFRs was tested against ATSM F2299 and NIOSH TEB-STP-APR-0059.
Results
Viable SARS-CoV-2 virus was not detected after VHP treatment. One replicate of the HCoV-229E laced FFRs yielded virus after processing. Unexpired N95 FFRs retained full filtration …
学术搜索中的文章
N Christie-Holmes, R Tyli, P Budylowski, F Guvenc… - American Journal of Infection Control, 2021