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Salacia oblonga Wall. belonging to the family celastraceae is used in the treatment of diabetes, rheumatism, gonorrhoea, itches, asthma, wound healing, amenorrhea and ear diseases. It is a woody climber distributed in Sri Lanka and Southern regions of India. In the present study antimicrobial activity of Salacia oblonga was evaluated against pathogenic strains, gram

+ ve Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus subtilis, Listeria monocytogenes and gram-ve Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, Pseudomonas aeruginosa, Escherichia coli,