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Objective: The current COVID-19 pandemic is associated with numerous psychological issues, such as anxiety and distress as a result of individual, health-related, social, and economic issues. This study aims to assess the general population in Iran for the negative impacts of the current pandemic on psychological well-being and to find possible protective and risk factors when facing such situations in the current COVID-19 pandemic.

Methods: A total of 317 people participated in an online survey in Iran from August 3, 2020, to September 20, 2020. Anxiety, depression, fear of COVID-19, emotion regulation, intolerance of uncertainty, illness perception, neuroticism, social support, and self-efficacy were evaluated.

Results: The results showed that measures that assess anxiety, depression, emotion regulation, intolerance of uncertainty, illness perception, neuroticism, social support, and self-efficacy were significantly related to fear of COVID-19. Meanwhile, the results of regression analysis demonstrated that neuroticism, intolerance of uncertainty, and illness perception could predict fear of COVID-19 beyond and above anxiety and depression.

Conclusion: Some factors, including neuroticism, illness perception, and intolerance of uncertainty are considered risk factors for mental health during this pandemic.