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The treatment with the chemotherapeutic agent paclitaxel produces a painful peripheral neuropathy, and is associated with an acute pain syndrome in a clinically significant number of patients. However, no standard therapy has been established to manage the acute pain or the chronic neuropathic pain related to paclitaxel. In the present study, we evaluated the analgesic potential of two N-type voltage-gated calcium channel (VGCC) blockers, ω-conotoxin MVIIA and Phα1β, on acute and chronic pain induced by paclitaxel. Adult male rats were treated with four intraperitoneal injections of paclitaxel (1 + 1 + 1 + 1 mg/kg, in alternate days) and the development of mechanical hyperalgesia was evaluated 24 h (acute painful stage) or 15 days (chronic painful stage) after the first paclitaxel injection. Not all animals showed mechanical hyperalgesia 24 h after the first paclitaxel injection, but those that showed developed a …