作者
Caitlin A McIntyre, Sharon A Lawrence, Allison L Richards, Joanne F Chou, Winston Wong, Marinela Capanu, Michael F Berger, Mark TA Donoghue, Kenneth H Yu, Anna M Varghese, David P Kelsen, Wungki Park, Vinod P Balachandran, T Peter Kingham, Michael I D’Angelica, Jeffrey A Drebin, William R Jarnagin, Christine A Iacobuzio‐Donahue, Peter J Allen, Eileen M O’Reilly
发表日期
2020/9/1
期刊
Cancer
卷号
126
期号
17
页码范围
3939-3949
简介
Background
KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways are associated with clinical outcomes for individuals who undergo resection.
Methods
Eligible individuals were those who underwent resection of PDAC and consented to targeted sequencing of their primary tumor via Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets (MSK‐IMPACT). Genomic alterations were determined on the basis of MSK‐IMPACT results from formalin‐fixed, paraffin‐embedded samples. Associations between genomic alterations and clinical outcomes were assessed.
Results
Targeted sequencing was performed on 283 primary tumors resected between 2004 and 2017. The median follow‐up was 23 …
学术搜索中的文章
CA McIntyre, SA Lawrence, AL Richards, JF Chou… - Cancer, 2020