作者
Anna M Varghese, Isha Singh, Rituraj Singh, Siddharth Kunte, Joanne F Chou, Marinela Capanu, Winston Wong, Maeve A Lowery, Zsofia K Stadler, Erin Salo-Mullen, Lily V Saadat, Alice C Wei, Marsha Reyngold, Olca Basturk, Ryma Benayed, Diana Mandelker, Christine A Iacobuzio-Donahue, David P Kelsen, Wungki Park, Kenneth H Yu, Eileen M O’Reilly
发表日期
2021/9/1
期刊
JNCI: Journal of the National Cancer Institute
卷号
113
期号
9
页码范围
1194-1202
出版商
Oxford University Press
简介
Background
Recent evidence suggests a rising incidence of cancer in younger individuals. Herein, we report the epidemiologic, pathologic, and molecular characteristics of a patient cohort with early-onset pancreas cancer (EOPC).
Methods
Institutional databases were queried for demographics, treatment history, genomic results, and outcomes. Overall survival from date of diagnosis was estimated using Kaplan-Meier method.
Results
Between 2008 and 2018, 450 patients with EOPC were identified at Memorial Sloan Kettering. Median overall survival was 16.3 (95% confidence interval [CI] = 14.6 to 17.7) months in the entire cohort and 11.3 (95% CI = 10.2 to 12.2) months for patients with stage IV disease at diagnosis. Of the patients, 132 (29.3% of the cohort) underwent somatic testing; 21 of 132 (15.9%) had RAS wild-type cancers with identification of …
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AM Varghese, I Singh, R Singh, S Kunte, JF Chou… - JNCI: Journal of the National Cancer Institute, 2021