作者
Rocio G Urdinguio, Virginia Lopez, Gustavo F Bayon, Rafael Diaz de la Guardia, Marta I Sierra, Estela García-Toraño, Raul F Perez, María G García, Antonella Carella, Patricia C Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalía Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramon Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, Clara Bueno, Alejandra Sanjuan-Pla, Ramon M Rodriguez, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Teresa Bernal, Enrique Colado, Milagros Balbín, Olivia García-Suarez, María Dolores Chiara, Inés Sáenz-de-Santa-María, Francisco Rodríguez, Ana Pando-Sandoval, Luis Rodrigo, Laura Santos, Ana Salas, Jesús Vallejo-Díaz, Ana C. Carrera, Daniel Rico, Inmaculada Hernández-López, Amparo Vayá, José M Ricart, Edward Seto, Núria Sima-Teruel, Alejandro Vaquero, Luis Valledor, Maria Jesus Cañal, David Pisano, Osvaldo Graña-Castro, Tim Thomas, Anne K Voss, Pablo Menéndez, Ana Villar-Garea, Rainer Deutzmann, Agustín F Fernandez, Mario F Fraga
发表日期
2019/6/4
期刊
Nucleic acids research
卷号
47
期号
10
页码范围
5016-5037
出版商
Oxford University Press
简介
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac …
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RG Urdinguio, V Lopez, GF Bayon… - Nucleic acids research, 2019
