作者
Luigi Di Biase, Angelo Auricchio, Antonio Sorgente, Kenneth Civello, Catherine Klersy, Francesco Faletra, Lucie Riedlbauchova, Dimpi Patel, Mauricio Arruda, Robert A Schweikert, David O Martin, Walid I Saliba, Tiziano Moccetti, Bruce L Wilkoff, Andrea Natale
发表日期
2008/10/1
期刊
European heart journal
卷号
29
期号
20
页码范围
2497-2505
出版商
Oxford University Press
简介
Aims
We assessed the relationship between cardiac resynchronization therapy (CRT)-induced reverse remodelling and mortality during a long-term follow-up in a prospective observational study.
Methods and results
We analyzed data from a prospective registry including 398 consecutive patients who underwent CRT between September 1998 and September 2007. Left ventricular ejection fraction (LVEF) was assessed before CRT and in the period between 3 and 6 months following implant. All-cause mortality, urgent transplantation and implantation of left ventricular assist device were all considered relevant events. A total of 398 (179 non-ischaemic and 219 ischaemic) patients were analysed. Overall, the increase of LVEF was statistically significant and was computed with 7.0 points (95% CI 5.8–8.3, P < 0.001). Non-ischaemic patients had a larger increase [9.2 points (95 …
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