作者
Neeraj Sharma, James B Smadbeck, Nadine Abdallah, Cinthya Zepeda-Mendoza, Moritz Binder, Kathryn E Pearce, Yan W Asmann, Jess F Peterson, Rhett P Ketterling, Patricia T Greipp, P Leif Bergsagel, S Vincent Rajkumar, Shaji K Kumar, Linda B Baughn
发表日期
2021/10/1
期刊
Clinical Cancer Research
卷号
27
期号
19
页码范围
5430-5439
出版商
American Association for Cancer Research
简介
Purpose
Structural variants (SV) of the MYC gene region are common in multiple myeloma and influence disease progression. However, the prognostic significance of different MYC SVs in multiple myeloma has not been clearly established.
Experimental Design
We conducted a retrospective study of multiple myeloma comparing MYC SV subtypes identified by next-generation sequencing (NGS) and FISH to MYC expression and disease survival using 140 cases from Mayo Clinic and 658 cases from the MMRF CoMMpass study.
Results
MYC SVs were found in 41% of cases and were classified into nine subtypes. A correlation between the presence of a MYC SV and increased MYC expression was identified. Among the nine MYC subtypes, the non-immunoglobulin (non-Ig) insertion subtype was independently associated with improved outcomes …
学术搜索中的文章
N Sharma, JB Smadbeck, N Abdallah… - Clinical Cancer Research, 2021