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Results

FMD was significantly (P< 0.01) lower in hypertensive patients (4.6±1.8%) than in normotensive subjects (7.1±2.6%), whereas the response to GTN was similar. L-NMMA significantly (P< 0.001) inhibited FMD in normotensive but not in hypertensive subjects. Mean 24-h ambulatory blood pressure, plasma angiotensin II and oxidative stress marker levels were similarly reduced at the end of the two treatment periods. Both dosages of ramipril significantly (P< 0.001) increased FMD (5 mg: 5.9±2.1%; 10 mg: 6.3±2.4%) without modifying the response to GTN. However, compared with baseline (11±19%), the inhibiting effect of L-NMMA on FMD (NO-dependent FMD) was significantly (P< 0.01) greater with ramipril 10 mg (49±12%) than 5 mg per day (38±15%). The improvement in FMD and NO-dependent FMD was not related to changes in plasma levels of angiotensin II or markers of oxidative stress.

Conclusion …