作者
Julia Novotny, Paul Oberdieck, Anna Titova, Jaroslav Pelisek, Sue Chandraratne, Philipp Nicol, Alexander Hapfelmeier, Michael Joner, Lars Maegdefessel, Holger Poppert, Joachim Pircher, Steffen Massberg, Benjamin Friedrich, Claus Zimmer, Christian Schulz, Tobias Boeckh-Behrens
发表日期
2020/6/2
期刊
Neurology
卷号
94
期号
22
页码范围
e2346-e2360
出版商
Lippincott Williams & Wilkins
简介
Objective
To investigate whether immune cell composition and content of neutrophil extracellular traps (NETs) in relation to clinical outcome are different between acute ischemic stroke (AIS) and acute myocardial infarction (AMI), we performed histologic analysis and correlated results with clinical and procedural parameters.
Methods
We retrieved thrombi from patients with AIS (n = 71) and AMI (n = 72) during endovascular arterial recanalization and analyzed their immune cell composition and NET content by immunohistology. We then associated thrombus composition with procedural parameters and outcome in AIS and with cardiac function in patients with AMI. Furthermore, we compared AIS thrombi with AMI thrombi and differentiated Trial of Org 10172 in Acute Stroke Treatment classifications to address potential differences in thrombus pathogenesis.
Results
Amounts of leukocytes (p = 0.133) and neutrophils (p …
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J Novotny, P Oberdieck, A Titova, J Pelisek… - Neurology, 2020