作者
Rachita K Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Tatiana B Krasieva, Miriam Scadeng, Alexandra K Dvornikova, Annlia Paganini-Hill, Ronald Kim, David H Cribbs, Mark J Fisher
发表日期
2016/12
期刊
Journal of neuroinflammation
卷号
13
页码范围
1-12
出版商
BioMed Central
简介
Background
Cerebral microhemorrhages (CMH) are tiny deposits of blood degradation products in the brain and are pathological substrates of cerebral microbleeds. The existing CMH animal models are β-amyloid-, hypoxic brain injury-, or hypertension-induced. Recent evidence shows that CMH develop independently of hypoxic brain injury, hypertension, or amyloid deposition and CMH are associated with normal aging, sepsis, and neurodegenerative conditions. One common factor among the above pathologies is inflammation, and recent clinical studies show a link between systemic inflammation and CMH. Hence, we hypothesize that inflammation induces CMH development and thus, lipopolysaccharide (LPS)-induced CMH may be an appropriate model to study cerebral microbleeds.
Methods
Adult C57BL/6 mice were injected with LPS (3 or 1 mg …
学术搜索中的文章
RK Sumbria, MM Grigoryan, V Vasilevko, TB Krasieva… - Journal of neuroinflammation, 2016