作者
Imre J Pavo, Noemi Pavo, Nina Kastner, Denise Traxler, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Martin Riesenhuber, David Lorant, Philipp E Bartko, Georg Goliasch, Martin Hülsmann, Johannes Winkler, Mariann Gyöngyösi
发表日期
2020/7/1
期刊
Basic to Translational Science
卷号
5
期号
7
页码范围
715-726
出版商
American College of Cardiology Foundation
简介
Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher NEP content and/or activity compared with any other organ; 2) NEP seems to be downregulated under HF conditions; and 3) that the value of plasma NEP concentrations and activity as biomarkers is questionable. For the first time, these data provide basic knowledge on HF-related pathophysiological alterations of the NEP system and contribute to understanding the mechanism of action of angiotensin-receptor neprilysin-inhibitors, which remains elusive despite broad clinical applications.
学术搜索中的文章
IJ Pavo, N Pavo, N Kastner, D Traxler, D Lukovic… - Basic to Translational Science, 2020