查看文章

We introduce a novel CO₂ laser device that utilizes ablative fractional resurfacing for deep dermal tissue removal and characterize the resultant thermal effects in skin.

A prototype 30 W, 10.6 µm CO₂ laser was focused to a 1/e² spot size of 120 µm and pulse duration up to 0.7 milliseconds to achieve a microarray pattern in ex vivo human skin. Lesion depth and width were assessed histologically using either hematoxylin & eosin (H&E) or lactate dehyrdogenase (LDH) stain. Pulse energies were varied to determine their effect on lesion dimensions.

Microarrays of ablative and thermal injury were created in fresh ex vivo human skin irradiated with the prototype CO₂ laser device. Zones of tissue ablation were surrounded by areas of tissue coagulation spanning the epidermis and part of the dermis. A thin condensed lining on the interior wall …