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A new method has been used to measure tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone‐pigmented skin has a drug and metabolite concentration ten times that of non‐pigmented skin. Iodine‐rich amiodarone and its metabolite have been detected in secondary lysosomes by energy dispersive analysis of X‐rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV‐B and UV‐A wavelengths.