作者
Jessie P Bakker, Bradley A Edwards, Shiva P Gautam, Sydney B Montesi, Joaquín Durán-Cantolla, Felipe Aizpuru Barandiarán, Ferran Barbé, Manuel Sánchez-de-la-Torre, Atul Malhotra
发表日期
2014/4/15
期刊
Journal of Clinical Sleep Medicine
卷号
10
期号
4
页码范围
365-369
出版商
American Academy of Sleep Medicine
简介
Study Objectives
We sought to perform a patient-level meta-analysis using the individual patient data of the trials identified in our previous study-level meta-analysis investigating the effect of positive airway pressure (PAP) treatment for obstructive sleep apnea (OSA) on blood pressure (BP).
Design
Patient-level meta-analysis.
Setting
N/A.
Participants
968 adult OSA subjects without major comorbidities drawn from eight randomized controlled trials.
Interventions
Therapeutic PAP versus non-therapeutic control conditions (sham-PAP, pill placebo or standard care) over at least one week.
Measurements and Results
The mean reductions in BP between PAP and non-therapeutic control arms were -2.27 mm Hg (95% CI -4.01 to -0.54) for systolic BP and -1.78 mm Hg (95% CI -2.99 to -0.58) for diastolic BP. The presence of uncontrolled hypertension at baseline was significantly associated with a reduction in systolic BP of 7.1 …
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JP Bakker, BA Edwards, SP Gautam, SB Montesi… - Journal of Clinical Sleep Medicine, 2014