作者
Paula Rovira, Ditte Demontis, Cristina Sánchez-Mora, Tetyana Zayats, Marieke Klein, Nina Roth Mota, Heike Weber, Iris Garcia-Martínez, Mireia Pagerols, Laura Vilar-Ribó, Lorena Arribas, Vanesa Richarte, Montserrat Corrales, Christian Fadeuilhe, Rosa Bosch, Gemma Español Martin, Peter Almos, Alysa E Doyle, Eugenio Horacio Grevet, Oliver Grimm, Anne Halmøy, Martine Hoogman, Mara Hutz, Christian P Jacob, Sarah Kittel-Schneider, Per M Knappskog, Astri J Lundervold, Olga Rivero, Diego Luiz Rovaris, Angelica Salatino-Oliveira, Bruna Santos da Silva, Evgeniy Svirin, Emma Sprooten, Tatyana Strekalova, ADHD Working Group of the Psychiatric Genomics Consortium, 23andMe Research team, Alejandro Arias-Vasquez, Edmund JS Sonuga-Barke, Philip Asherson, Claiton Henrique Dotto Bau, Jan K Buitelaar, Bru Cormand, Stephen V Faraone, Jan Haavik, Stefan E Johansson, Jonna Kuntsi, Henrik Larsson, Klaus-Peter Lesch, Andreas Reif, Luis Augusto Rohde, Miquel Casas, Anders D Børglum, Barbara Franke, Josep Antoni Ramos-Quiroga, María Soler Artigas, Marta Ribasés
发表日期
2020/9/1
期刊
Neuropsychopharmacology
卷号
45
期号
10
页码范围
1617-1626
出版商
Springer International Publishing
简介
Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in …
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P Rovira, D Demontis, C Sánchez-Mora, T Zayats… - Neuropsychopharmacology, 2020