作者
Anna Stroud, Pearl Dhaliwal, Raquel Alvarado, Mark J Winder, Benjamin P Jonker, Jessica W Grayson, Aneeza Hamizan, Richard J Harvey, Ann McCormack
发表日期
2020/10
来源
Pituitary
卷号
23
期号
5
页码范围
595-609
出版商
Springer US
简介
Purpose
Transsphenoidal surgery (TSS) is the first-line treatment for Cushing’s disease (CD). This review aimed to synthesize the remission and recurrence rates following TSS for CD and identify predictors of these outcomes.
Methods
Medline (1946-) and Embase (1947-) were searched until 23rd January 2019 for original studies. A meta-analysis was performed of remission and recurrence rates. Studies were excluded if patients had prior radiosurgery/radiotherapy, mixed pathologies or interventions without separated data, follow-up not reported or population size < 20. For recurrence rate syntheses, studies with follow-up < 6 months were excluded.
Results
The search produced 2663 studies, of which n = 68 were included, involving 5664 patients. Remission rates after primary and revision TSS were 80% [77–82] and 58% [50–66] at last follow-up. After primary TSS, predictors of remission were micro …
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A Stroud, P Dhaliwal, R Alvarado, MJ Winder… - Pituitary, 2020
