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RESULTS

The two groups were comparable at baseline. At similar time points, 10 (50%) patients in each group achieved primary end points. Patients in both groups had a significant (P< 0.05) decrease in serum creatinine from baseline (group A day 4 2.4±1.2 mg/dL, day 8 1.6±1.2 mg/dL, and day 15 1.0±0.4 mg/dL; group B day 4 2.5±1.5 mg/dL, day 8 1.8±0.9 mg/dL, and day 15 1.2±0.5 mg/dL) and progressive increase in creatinine clearance (group A day 4 26.5±12.8 mL/min and day 15 59.8±14.2 mL/min; group B day 4 31.4±21.4 mL/min and day 15 54.9±27.5 mL/min, P< 0.05). Median baseline plasma renin activity was reduced from 38.0 and 42.0 ng/mL/h to 3.0 and 8.0 ng/mL/h (P= 0.08) in groups A and B, respectively. Mean arterial BP and urine output significantly increased in both groups with therapy. Eleven (55%) patients in group A (10 responders) and an equal number in group B (8 responders) survived …