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In this study we examine the role of sexual mindfulness in individuals’ sexual satisfaction, relational satisfaction, and self-esteem. Midlife U.S. men and women (N = 194 married, heterosexual individuals; 50.7% female; 94% Caucasian, age range 35–60 years) completed an online survey. More sexually mindful individuals tended to have better self-esteem, be more satisfied with their relationships and, particularly for women, be more satisfied with their sex lives. Some of these associations occurred even after controlling for trait mindfulness. These findings may also allow researchers and therapists to better address an individual’s sexual wellbeing, relational wellbeing, and self-esteem by teaching sexual mindfulness skills.