作者
Jennifer Gillis, Marek Smieja, Angela Cescon, Sean B Rourke, Ann N Burchell, Curtis Cooper, Janet M Raboud, OHTN Cohort Study Group
发表日期
2014/4
期刊
Antiviral therapy
卷号
19
期号
3
页码范围
309-317
出版商
SAGE Publications
简介
Background
The increased risk for cardiovascular disease (CVD) in HIV is well established. Despite high prevalence of viral hepatitis coinfection with HIV, there are few studies on the risk of CVD amongst antiretroviral therapy (ART)-treated coinfected patients.
Methods
Ontario HIV Treatment Network Cohort Study participants who initiated ART without prior CVD events were analysed. HBV and HCV coinfection were identified by serology and RNA test results. CVD was defined as any of: coronary artery disease including atherosclerosis, chronic ischaemic heart disease and arteriosclerotic vascular disease; myocardial infarction; congestive heart failure; cerebrovascular accident or stroke; coronary bypass; angioplasty; and sudden cardiac death. The impact of HBV and HCV coinfection on time to CVD was assessed using multivariable competing risk models accounting for left truncation between ART initiation and …
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J Gillis, M Smieja, A Cescon, SB Rourke, AN Burchell… - Antiviral therapy, 2014