作者
David M Kent, Robin Ruthazer, Christian Weimar, Jean-Louis Mas, Joaquín Serena, Shunichi Homma, Emanuele Di Angelantonio, Marco R Di Tullio, Jennifer S Lutz, Mitchell SV Elkind, John Griffith, Cheryl Jaigobin, Heinrich P Mattle, Patrik Michel, Marie-Louise Mono, Krassen Nedeltchev, Federica Papetti, David E Thaler
发表日期
2013/8/13
期刊
Neurology
卷号
81
期号
7
页码范围
619-625
出版商
Lippincott Williams & Wilkins
简介
Objective
We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO.
Methods
Using data from 12 component studies, we used generalized linear mixed models to predict the presence of PFO among patients with CS, and derive a simple index to stratify patients with CS. We estimated the stratum-specific PFO-attributable fraction and stratum-specific stroke/TIA recurrence rates.
Results
Variables associated with a PFO in CS patients included younger age, the presence of a cortical stroke on neuroimaging, and the absence of these factors: diabetes, hypertension, smoking, and prior stroke or TIA. The 10-point Risk of Paradoxical Embolism score is calculated from these variables so that the youngest patients with superficial strokes and without vascular risk factors have the highest score. PFO prevalence increased …
学术搜索中的文章
DM Kent, R Ruthazer, C Weimar, JL Mas, J Serena… - Neurology, 2013