作者
Joseph C Watso, Mu Huang, Gilbert Moralez, Matthew N Cramer, Joseph M Hendrix, Frank A Cimino III, Luke N Belval, Carmen HinojosaLaborde, Craig G Crandall
发表日期
2021/1
期刊
The Journal of Physiology
卷号
599
期号
1
页码范围
67-81
简介
Key points
- Low dose ketamine is a leading medication used to provide analgesia in prehospital and hospital settings. Low dose ketamine is increasingly used offlabel to treat conditions such as depression.
- In animals, ketamine stimulates the sympathetic nervous system and increases blood pressure, but these physiological consequences have not been studied in conscious humans.
- Our data suggest that low dose ketamine administration blunts pain perception and reduces blood pressure, but not muscle sympathetic nerve activity burst frequency, responses during a cold pressor test in healthy humans.
- These mechanistic, physiological results inform riskbenefit analysis for clinicians administering low dose ketamine in humans.
Abstract
Low dose ketamine is an effective analgesic medication. However, our knowledge of the effects of ketamine on autonomic cardiovascular regulation is primarily limited to …
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JC Watso, M Huang, G Moralez, MN Cramer… - The Journal of Physiology, 2021
