作者
Shijun Ren, Eric J Lien, Nicholas C Turner, John C Clapham, Laszlo Prokai, Ravenska TE Wagey, Charles Krieger, Vera M Kolb, Kirk W Johnson, Lee A Phebus, Marlene L Cohen, Barry A Kenny, Mark Bushfield, David J Parry-Smith, Simon Fogarty, J Mark Treherne, Kirk W Johnson, Lee A Phebus, Marlene L Cohen
发表日期
1998
来源
Progress in drug research
页码范围
219-244
出版商
Birkhäuser Basel
简介
A role for serotonin in migraine has been supported by changes in circulating levels of serotonin and its metabolites during the phases of a migraine attack, along with the ability of serotonin-releasing agents to induce migraine-like symptoms. The development of serotonin receptor agonists with efficacy in the clinic for the alleviation of migraine pain further implicates serotonin as a key molecule in migraine.
Several theories regarding the etiology of migraine have been proposed. The vasodilatory theory of migraine suggested that extracranial arterial dilation during an attack was related to migraine pain; a theory supported when vasoconstrictors such as sumatriptan alleviated migraine pain. The neurological theory of migraine proposed that migraine resulted from abnormal firing in brain neurons. Cortical spreading depression, one facet of the neurological theory, could explain the prodrome of …
引用总数
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S Ren, EJ Lien, NC Turner, JC Clapham, L Prokai… - Progress in drug research, 1998
