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Objectives To model the potential health gains and cost-effectiveness of a mandatory limit of industrial trans fatty acids (iTFA) in Kenyan foods. Design Multiple cohort proportional multistate life table model, incorporating existing data from the Global Burden of Disease study, pooled analyses of observational studies and peer-reviewed evidence of healthcare and policy implementation costs. Setting Kenya. Participants Adults aged≥ 20 years at baseline (n= 50 million). Intervention A mandatory iTFA limit (≤ 2% of all fats) in the Kenyan food supply compared with a base case scenario of maintaining current trans fat intake. Main outcome measures Averted ischaemic heart disease (IHD) events and deaths, health-adjusted life years; healthcare costs; policy implementation costs; net costs; and incremental cost-effectiveness ratio. Results Over the first 10 years, the intervention was estimated to prevent~ 1900 (95 …