作者
Gwen MC Masclee, Vera E Valkhoff, Preciosa M Coloma, Maria de Ridder, Silvana Romio, Martijn J Schuemie, Ron Herings, Rosa Gini, Giampiero Mazzaglia, Gino Picelli, Lorenza Scotti, Lars Pedersen, Ernst J Kuipers, Johan van der Lei, Miriam CJM Sturkenboom
发表日期
2014/10/1
期刊
Gastroenterology
卷号
147
期号
4
页码范围
784-792. e9
出版商
WB Saunders
简介
Background & Aims
Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inhibitors (COX-2 inhibitors), and low-dose aspirin with other drugs.
Methods
We performed a case series analysis of data from 114,835 patients with UGIB (930,888 person-years of follow-up) identified from 7 population-based health care databases (approximately 20 million subjects). Each patient served as his or her own control. Drug exposure was determined based on prescriptions of nsNSAIDs, COX-2 inhibitors, or low-dose aspirin, alone and in combination with other drugs that affect the risk of UGIB. We measured …
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