作者
V Fedirko, I Tramacere, V Bagnardi, M Rota, L Scotti, F Islami, E Negri, K Straif, I Romieu, C La Vecchia, P Boffetta, M Jenab
发表日期
2011/9/1
来源
Annals of oncology
卷号
22
期号
9
页码范围
1958-1972
出版商
Elsevier
简介
Background
The International Agency for Research on Cancer (IARC) concluded that alcohol consumption is related to colorectal cancer (CRC). However, several issues remain unresolved, including quantification of the association for light (≤1 drink/day) and moderate (2–3 drinks/day) alcohol drinking, investigation of the dose–response relationship, and potential heterogeneity of effects by sex, colorectal site, and geographical region.
Methods
Twenty-seven cohort and 34 case–control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before May 2010. The summary relative risks (RRs) were estimated by the random effects model. Second-order fractional polynomials and random effects meta-regression models were used for modeling the dose–risk relation.
Results
The RRs were 1.21 [95% confidence interval (CI) 1.13–1.28] for …
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