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Recent research has shown that IL8, IL6, IL-1β and TNFα played significant roles in the first stages of tooth movement, but not in the linear stage. After treatment, the values of IL–1β dropped significantly more in the case of patients who received combined treatment (periodontal and orthodontic) compared to the patients that received only periodontal treatment. We must underline the fact that at the start of the treatment the patients whose periodontium was affected and who were about to receive periodontal treatment associated with orthodontic treatment had higher values of IL–1β (but not statistically significant). The comparative study of IL-1β values post-treatment shows that in the case of associated treatment the post-treatment values drop significantly more for all Angle classes, being higher in the patients who had class III Angle.