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PGE2 and IL1â are key mediators involved in periodontal disease, strong stimulators of bone resorption, produced by the cells of the human periodontal ligament in response to mechanical stress. Saliva has an impressive number of components with a protective role, but it also contains markers used in identifying oral inflammation processes. This is why studying the levels of PGE2-type markers in saliva can be a very valuable diagnostic instrument. The results of the post-treatment values of PGE2 have shown a significant decrease after both alternatives of treatment. To conclude, the values of PGE2 decreased more in the case of combined treatment. When associated with orthodontic treatment, periodontal therapy determined a significant statistical decrease of PGE2 values, indicating in an obvious manner the decrease of inflammation and the improvement of the periodontal status.