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Sepsis, one of the leading causes of morbidity and mortality in critically ill subjects has many biochemical disorders, and when hepato-renal dysfunction is associated, it is accompanied most frequently by hypokalaemia, hyponatremia, increasing values of serum creatinine and urea, various types of serum proteins, metabolic acidosis. The aim of the study is to find correlations and arguments for biochemical disorders in hepato-renal dysfunction in sepsis patients. Our retrospective study included 247 subjects diagnosed with sepsis between November 2012 and April 2014, analysing laboratory data on clinical aspects. Data were processed using SPSS version 16.0. Different plasmatic levels of biochemical parameters were related to organ dysfunctions in sepsis subjects. Even though plasma creatinine levels were higher in hepato-renal dysfunction in sepsis, there were no significant differences between creatinine clearance levels comparising by old renal dysfunction in these subjects, also no significant differences for dyselectrolytemia in hepatorenal dysfunction comparising by other organ dysfunctions in sepsis subjects. Metabolic acidosis and plasma total bilirubin level were found as negative prognostic factors.