查看文章

Purpose: We wished to evaluate adjunctive therapy for partial‐onset seizures with topiramate (TPM) for efficacy and safety in a double‐blind, placebo‐controlled, randomized, parallel‐group study.

Methods: Sixty outpatients with epilepsy (47 men and 13 women, mean age 32.9 years) were studied. All had a documented history of partial‐onset seizures with or without secondarily generalized seizures. After an 8‐week baseline during which patients had at least one seizure per week, 30 patients each were randomized to TPM 300 mg twice daily (b.i.d.) or placebo for 12 weeks.

Results: TPM was significantly superior to placebo, as indicated by all efficacy assessments: greater median percent reduction from baseline in the average monthly seizure rate (46 vs. ‐12%, p = 0.004); greater number of treatment responders (patients with 50% reduction in seizure rate) (47 vs. 10%, p = 0.001), and better investigator (p = 0 …