作者
Brannon Altenhofen, Todd A DeWees, Ji W Ahn, Nai C Yeat, Shreya Goddu, Ishita Chen, James S Lewis Jr, Wade L Thorstad, Richard A Chole, Hiram A Gay
发表日期
2020/4
期刊
Laryngoscope investigative otolaryngology
卷号
5
期号
2
页码范围
210-216
出版商
John Wiley & Sons, Inc.
简介
Objectives
We investigated how tonsillectomy during childhood may influence the distribution of human papillomavirus (HPV) positive cancer of the tonsils in adult life using p16 as a surrogate marker for HPV infection.
Study Design
Retrospective observational study.
Methods
A total of 280 patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) and known p16 status were eligible for this study. Each participant was called to obtain the childhood tonsillectomy history. Respondents were subgrouped by p16 status and the primary tumor location. Patient demographic and clinical information was analyzed for association with Fisher's exact and Wilcoxon rank sum tests. Location of tumor was modeled using univariate (UVA) and multivariate (MVA) logistic regression with associated odds ratios (OR) and 95% confidence intervals.
Results
Of the 280 patients, 115 (41%) were respondents: 104 (90 …
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B Altenhofen, TA DeWees, JW Ahn, NC Yeat, S Goddu… - Laryngoscope investigative otolaryngology, 2020