查看文章

Dapsone has been used in the treatment of patients with immune thrombocytopenia (ITP) since the late 1980s. It is a drug that is inexpensive and well tolerated, but unfortunately, it is underused worldwide due to the lack of information regarding its mechanism of action, efficacy rates and safety profile. Our institution has an extensive experience with the drug, for it has been used as the standard 2^nd line therapy in our ITP patients for the last 20 years.

In this study we aimed to assess the efficacy rate, frequency and gravity of side effects of dapsone therapy in ITP patients. As a secondary endpoint, we wanted to evaluate the possible clinical factors associated with a treatment response.

This was a single-center retrospective study, where medical charts of ITP patients in follow-up at our outpatient clinic in the period of 2011 to 2017 were reviewed for identification of patients treated with dapsone. Inclusion criteria were …