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Abstract Introduction: Recent therapeutics for Major Depressive Disorder have been developed to target the gut microbiome and its bidirectional communication with the enteric and central nervous systems. One proposed mechanism for these therapeutics is through the interaction of the gut microbiome with the vagus nerve, affecting vagal tone and activity. A non-invasive way to observe possible changes in vagus nerve activity and vagal tone is through monitoring of heart rate variability (HRV) using an ECG. Objectives: The primary objective of this study is to investigate changes in HRV in individuals with depression before, during, and after supplementation with Probio'Stick®(Lallemand Health Solutions, Canada) and Microbial Ecosystem Therapeutic-2 (MET-2; Nubiyota, Canada). The secondary objective is to asses changes in EEG signals and their correlation with HRV in said individuals. Methods: Participants …