作者
Ahmad Jayedi, Kazem Rahimi, Leonelo E Bautista, Milad Nazarzadeh, Mahdieh Sadat Zargar, Sakineh Shab-Bidar
发表日期
2019/5/1
期刊
Heart
卷号
105
期号
9
页码范围
686-692
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Objective
To systematically assess the association of circulating inflammation markers with the future risk of hypertension.
Methods
We did a systematic literature search of PubMed and Scopus, from database inception to July 10, 2018. Prospective and retrospective cohort studies evaluating the association of circulating C reactive protein (CRP), high-sensitive CRP (hs-CRP), interleukin 6 (IL-6) and IL-1β to the risk of developing hypertension in the general population were included. The relative risks (RRs) for the top versus bottom tertiles of circulating biomarkers were calculated using a fixed-effects/random-effects model. A potential non-linear dose-response association was tested.
Results
Fourteen prospective cohort studies, two retrospective cohort studies and five nested case-control studies involving 142 640 participants and 20 676 cases were identified. The RR for the third versus first tertiles of circulating …
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A Jayedi, K Rahimi, LE Bautista, M Nazarzadeh… - Heart, 2019