作者
Ahmad Jayedi, Sheida Zeraattalab-Motlagh, Bahareh Jabbarzadeh, Yasaman Hosseini, Aliyu Tijen Jibril, Hossein Shahinfar, Amin Mirrafiei, Fatemeh Hosseini, Sakineh Shab-Bidar
发表日期
2022/7/1
来源
The American journal of clinical nutrition
卷号
116
期号
1
页码范围
40-56
出版商
Elsevier
简介
Background
Carbohydrate restriction is effective for type 2 diabetes management.
Objectives
We aimed to evaluate the dose-dependent effect of carbohydrate restriction in patients with type 2 diabetes.
Methods
We systematically searched PubMed, Scopus, and Web of Science to May 2021 for randomized controlled trials evaluating the effect of a carbohydrate-restricted diet (≤45% total calories) in patients with type 2 diabetes. The primary outcome was glycated hemoglobin (HbA1c). Secondary outcomes included fasting plasma glucose (FPG); body weight; serum total, LDL, and HDL cholesterol; triglyceride (TG); and systolic blood pressure (SBP). We performed random-effects dose-response meta-analyses to estimate mean differences (MDs) for a 10% decrease in carbohydrate intake.
Results
Fifty trials with 4291 patients were identified. At 6 months, compared with a carbohydrate intake between 55%–65% and …
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