作者
Xiao-Ping Liu, Xiaoqing Jin, Saman Seyed Ahmadian, Xu Yang, Su-Fang Tian, Yu-Xiang Cai, Kuldeep Chawla, Antoine M Snijders, Yankai Xia, Paul J van Diest, William A Weiss, Jian-Hua Mao, Zhi-Qiang Li, Hannes Vogel, Hang Chang
发表日期
2023/1/1
期刊
Neuro-oncology
卷号
25
期号
1
页码范围
68-81
出版商
Oxford University Press
简介
Background
Lower-grade gliomas (LGG) are heterogeneous diseases by clinical, histological, and molecular criteria. We aimed to personalize the diagnosis and therapy of LGG patients by developing and validating robust cellular morphometric subtypes (CMS) and to uncover the molecular signatures underlying these subtypes.
Methods
Cellular morphometric biomarkers (CMBs) were identified with artificial intelligence technique from TCGA-LGG cohort. Consensus clustering was used to define CMS. Survival analysis was performed to assess the clinical impact of CMBs and CMS. A nomogram was constructed to predict 3- and 5-year overall survival (OS) of LGG patients. Tumor mutational burden (TMB) and immune cell infiltration between subtypes were analyzed using the Mann-Whitney U test. The double-blinded validation for important immunotherapy-related biomarkers …
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