作者
Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy, Nehal N Mehta
发表日期
2014/12
期刊
Journal of Translational Medicine
卷号
12
页码范围
1-13
出版商
BioMed Central
简介
Background
Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity and diabetes mellitus. Psoriasis is associated with increased risk for metabolic disease, which may in part be due to adipose dysfunction, which has not been investigated in psoriasis. There is currently no standardized method for immunophenotyping human adipose tissue. In prior studies, characteristic phenotypic markers of immune cell populations identified in animal models or in other human tissues have been applied in a similar manner to human adipose tissue. Rarely have these populations been verified with confirmatory methodologies or functional studies. Thus, we performed a comprehensive phenotypic and functional analysis of immune cell populations in psoriatic adipose tissue.
Methods …
学术搜索中的文章
S Rose, E Stansky, PK Dagur, L Samsel, E Weiner… - Journal of Translational Medicine, 2014