作者
Margaret M Lowe, Haley B Naik, Sean Clancy, Mariela Pauli, Kathleen M Smith, Yingtao Bi, Robert Dunstan, Johann E Gudjonsson, Maia Paul, Hobart Harris, Esther Kim, Uk Sok Shin, Richard Ahn, Wilson Liao, Scott L Hansen, Michael D Rosenblum
发表日期
2020/10/10
期刊
JCI insight
卷号
5
期号
19
出版商
American Society for Clinical Investigation
简介
Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with limited treatment options. The major cell types and inflammatory pathways in skin of patients with HS are poorly understood, and which patients will respond to TNF-α blockade is currently unknown. We discovered that clinically and histologically healthy appearing skin (ie, nonlesional skin) is dysfunctional in patients with HS with a relative loss of immune regulatory pathways. HS skin lesions were characterized by quantitative and qualitative dysfunction of type 2 conventional dendritic cells, relatively reduced regulatory T cells, an influx of memory B cells, and a plasma cell/plasmablast infiltrate predominantly in end-stage fibrotic skin. At the molecular level, there was a relative bias toward the IL-1 pathway and type 1 T cell responses when compared with both healthy skin and psoriatic patient skin. Anti–TNF-α therapy …
学术搜索中的文章
MM Lowe, HB Naik, S Clancy, M Pauli, KM Smith, Y Bi… - JCI insight, 2020