作者
Tao Yang, Kacy L Magee, Luis M Colon‐Perez, Riley Larkin, Yan‐Shin Liao, Eliza Balazic, Jonathan R Cowart, Rebeca Arocha, Ty Redler, Marcelo Febo, Thomas Vickroy, Christopher J Martyniuk, Leah R Reznikov, Jasenka Zubcevic
发表日期
2019/6
期刊
Acta physiologica
卷号
226
期号
2
页码范围
e13256
简介
Aim
Butyrate is a major gut microbiota‐derived metabolite. Reduced butyrate‐producing bacteria has been reported in the spontaneously hypertensive rat (SHR), a model of hypertension characterized by dysfunctional autonomic nervous system and gut dysbiosis. Here, we demonstrate a potential mechanism for butyrate in blood pressure regulation.
Methods
High‐performance liquid chromatography and liquid chromatography‐mass spectrometry were performed to measure butyrate levels in feces and serum. Ussing chamber determined butyrate transport in colon ex vivo. Real‐time PCR and immunohistochemistry evaluated expression of butyrate transporter, Slc5a8, in the colon. Mean arterial blood pressure was measured in catheterized anesthetized rats before and after a single butyrate intracerebroventricular injection. Activity of cardioregulatory brain regions was determined by functional magnetic …
学术搜索中的文章
T Yang, KL Magee, LM Colon‐Perez, R Larkin, YS Liao… - Acta physiologica, 2019
