作者
Xiaolong Li, Huan Li, Guoqiang Liu, Ziwei Deng, Shuilin Wu, Penghui Li, Zushun Xu, Haibo Xu, Paul K Chu
发表日期
2012/4/1
期刊
Biomaterials
卷号
33
期号
10
页码范围
3013-3024
出版商
Elsevier
简介
Magnetite (Fe3O4) – loaded polymer micelles (denoted as “magnetomicelles”) are produced by self-assembly of fluorine-containing amphiphilic poly(HFMA-g-PEGMA) copolymers with oleic acid modified Fe3O4 nanoparticles in an aqueous medium. The oleic acid modified Fe3O4 nanoparticles form small clusters in the poly(HFMA-g-PEGMA) micelles with a mean diameter of 100 nm and the magnetomicelles show high stability in an aqueous medium due to the high hydrophobic fluorine segments in graft copolymers enhance the stability of the micelles. The magnetomicelles also show good cytocompatibility based on the MTT cytotoxicity assay and possess paramagnetic properties with saturation magnetization of 17.14 emu/g.Their good stability, cytocompatibility, and paramagnetic properties render the materials attractive in drug delivery and in vivo magnetic resonance imaging (MRI) applications. Controlled …
引用总数
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